Can the biochemical profile predict the etiology of the obstructive jaundice early?

Klerida Shehu, Benard Shehu, Sonela Xinxo, Adriana Babameto, Albana Duni, Sidorela Gjini, Luljeta Cakerri

Abstract


Background & Objectives

Early determining of obstructive jaundice etiology can improve both the quality of life and survival rate among the patients. Aim of the study is to shed light on prediction possibility the biochemical profile on the etiology of obstructive jaundice.

Methods

Retrospectively, were reviewed all the chart of patient who had been presented with obstructive jaundice at the admission and with final diagnosis of malign or benign extra hepatic obstructive of biliary tract during the 2014  at  University Hospital Center “Mother Teresa”. Patients’ biochemical routine markers were collected. A receiver operator characteristic curve was constructed to determine the optimal value for the biochemical marker to predict a malign etiology of OJ.

Results. 56 patients with extra hepatic obstructive of biliary tract were included in the study, of which 29 has a malignant etiology. The bilirubin, alkaline phosphatase, CA19-9, gamma GT and ALT were significant elevated in malign group. The ROC curve shows that a bilirubin level of more than 6.3, gamma GT more than 313, AST more than 76 and CA19-9 more than 36 indicated a malign etiology of the obstructive jaundice.

Interpretation and Conclusion.  Biochemical marker such as bilirubin, ɣGT, ASP and ALT should be considered as a predictor factor on the malign etiology of the obstructive jaundice. As far as, these markers are inexpensive and widespread used at every level of the health care, they can be very useful for the clinicians on the early prediction of the etiology.

Key words: obstructive jaundice, biochemical profile, prediction, etiology


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Copyright (c) 2015 Klerida Shehu, Benard Shehu, Sonela Xinxo, Adriana Babameto, Albana Duni, Sidorela Gjini, Luljeta Cakerri

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ISSN 2385-2712         EISSN 2385-2453